Ivosidenib

Description

Ivosidenib works by blocking an abnormal enzyme that some cancer cells with specific changes in the IDH-1 gene make. Blocking the abnormal enzyme may make cancer cells differentiate to become more like normal cells and grow more slowly. Ivosidenib is a type of targeted therapy drug called an enzyme inhibitor. It is a small-molecule drug (a drug that can enter cells easily).

US Brand Name(s)

Tibsovo

FDA Approved

Yes

Use in Cancer

Ivosidenib is approved to treat adults whose cancer has a certain mutation in the IDH1 gene, including:

Acute myeloid leukemia (AML). It is used:
- Alone or with azacitidine in patients with newly-diagnosed cancer who are 75 years or older or who cannot receive intensive induction chemotherapy due to health problems.
- When the cancer has come back or has not gotten better after previous treatment.
Cholangiocarcinoma (bile duct cancer) that has spread. It is used in adults whose cancer has been treated.
Myelodysplastic syndrome that has come back or did not respond to treatment.

Ivosidenib is also being studied in the treatment of other types of cancer.

More About Ivosidenib Definition from the NCI Drug Dictionary – Detailed scientific definition and other names for this drug. MedlinePlus Information on Ivosidenib – A lay language summary of important information about this drug that may include the following: warnings about this drug, what this drug is used for and how it is used, what you should tell your doctor before using this drug, what you should know about this drug before using it, other drugs that may interact with this drug, and possible side effects. Drugs are often studied to find out if they can help treat or prevent conditions other than the ones they are approved for. This patient information sheet applies only to approved uses of the drug. However, much of the information may also apply to unapproved uses that are being studied. Research Results and Related Resources Targeted Therapy to Treat Cancer Ivosidenib with Chemotherapy New Option for Some People with AML Clinical Trials Accepting Patients Find Clinical Trials for Ivosidenib – Check for trials from NCI’s list of cancer clinical trials now accepting patients. Important: The drug information on this page is meant to be educational. It is not a substitute for medical advice. The information may not cover all possible uses, actions, interactions, or side effects of this drug, or precautions to be taken while using it. Please see your health care professional for more information about your specific medical condition and the use of this drug.